Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function

  title={Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function},
  author={Elissa J. Chesler and Lu Lu and Siming Shou and Yanhua Qu and Jing Gu and Jintao Wang and Hui-Chen Hsu and John D. Mountz and Nicole E. Baldwin and Michael A. Langston and David W. Threadgill and Kenneth F. Manly and Robert W. Williams},
  journal={Nature Genetics},
Patterns of gene expression in the central nervous system are highly variable and heritable. This genetic variation among normal individuals leads to considerable structural, functional and behavioral differences. We devised a general approach to dissect genetic networks systematically across biological scale, from base pairs to behavior, using a reference population of recombinant inbred strains. We profiled gene expression using Affymetrix oligonucleotide arrays in the BXD recombinant inbred… 
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  • Biology
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  • 2003
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