Complex structure and regulation of the P16 (MTS1) locus.

  title={Complex structure and regulation of the P16 (MTS1) locus.},
  author={Steven Stone and Ping Jiang and Priya Dayananth and Sean V. Tavtigian and H. L. Katcher and David Parry and Gordon G Peters and Alexander Kamb},
  journal={Cancer research},
  volume={55 14},
The p16 gene (P16, MTS1, CDKN2) encodes a negative regulator of the cell cycle. Molecular genetic techniques have been used to explore the role of p16 in normal development and cancer. Two transcripts derived from the p16 gene with distinct protein coding potentials are described. The previously undescribed transcript form has the same exons 2 and 3 as the p16-encoding mRNA but contains a different exon 1. The human p16 transcripts are detected in various tissues, and the ratio of the… CONTINUE READING

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