Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I.

@article{Ciminale1992ComplexSI,
  title={Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I.},
  author={Vincenzo Ciminale and George N Pavlakis and David Derse and Craig P. Cunningham and Barbara K Felber},
  journal={Journal of virology},
  year={1992},
  volume={66 3},
  pages={1737-45}
}
Novel cytoplasmic mRNA species produced by human T-cell leukemia virus type I (HTLV-I) were cloned by using the polymerase chain reaction technique. Five novel 3' splice sites located in the X region and upstream of the env gene were identified. Splicing to the 3' splice sites in the X region generates mRNAs that express two previously unidentified viral proteins, named Rof and Tof. Tof accumulates in the nucleoli of transfected cells. The other viruses of the HTLV family, such as HTLV-II and… CONTINUE READING

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