Complex segregation analysis of thyroid autoantibodies: are they inherited as an autosomal dominant trait?

@article{Phillips1993ComplexSA,
  title={Complex segregation analysis of thyroid autoantibodies: are they inherited as an autosomal dominant trait?},
  author={David W. Phillips and Denis C. Shields and Jean Michel Dugoujon and Leah Prentice and Peter McGuffin and B Ree Smith},
  journal={Human heredity},
  year={1993},
  volume={43 3},
  pages={141-6}
}
The presence of circulating autoantibodies (Abs) to the thyroid antigens thyroid peroxidase (TPO) and thyroglobulin (Tg) is a marker for autoimmune thyroid disease. Recent studies have suggested that the tendency to produce these Abs is inherited as an autosomal dominant characteristic. In order to confirm or refute these observations, we have carried out a complex segregation analysis using POINTER on Ab data in 86 unselected pedigrees (172 nuclear families). The overall prevalence of TPO Ab… CONTINUE READING