Complex role of tumor cell transforming growth factor (TGF)-βs on breast carcinoma progression

  title={Complex role of tumor cell transforming growth factor (TGF)-βs on breast carcinoma progression},
  author={Katri M. Koli and Carlos L. Arteaga},
  journal={Journal of Mammary Gland Biology and Neoplasia},
Growth inhibition by the TGF-βs has been extensively studied in both normal and transformed mammary epithelial cells. It has been proposed that loss of autocrine TGF-β mediated growth regulation is a critical event in breast tumorigenesis and several lines ofin vitro andin vivo data support this hypothesis. However, a positive association between the expression of TGF-βs by tumor cells and the progression or maintenance of breast cancinoma cells has been observed in many studies inin vivo tumor… CONTINUE READING
11 Citations
54 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 11 extracted citations


Publications referenced by this paper.
Showing 1-10 of 54 references

Suppressed NK activities and shortened survival associated with high expression of TGF - 13 t in tumor cells of gastric cancer patients

  • S. A. Holden Teicher, G. Ara, G. Chen
  • Proc . Am . Assoc . Cancer Res .
  • 1996

Trans - forming growth factor - 13 type II receptor is infrequently expressed in human breast cancer

  • X-E Wang Yingling
  • Breast J .
  • 1996

Immuno - cytochemical localization of secreted transforming growth factor - 131 to the advancing edges of primary tumors and to lymph node metases of human mammary carcinoma

  • M. E Solomon, A. Castiglioni, V. L. Rothman, G. E Tuszynski
  • Am . J . Pathol .
  • 1995

Mammary tumor suppression by transforming growth factor 131 transgene expression

  • E ten Dijke Jeng, K. K. lwata, V. C. Jordan
  • Proc . Natl . Acad . Sci . U . S . A
  • 1995

Signaling by the transforming growth factor - 13 receptors

  • A. Kasid, K. K. Huff, +4 authors M. E. Lippman
  • Biochim . Bio - phys . Acta
  • 1995

Similar Papers

Loading similar papers…