Complex role of protein phosphorylation in gene activation by hypoxia.

@article{Salceda1997ComplexRO,
  title={Complex role of protein phosphorylation in gene activation by hypoxia.},
  author={S V Salceda and Ivy Beck and Volety Srinivas and J. L. Menendez Caro},
  journal={Kidney international},
  year={1997},
  volume={51 2},
  pages={
          556-9
        }
}
Complex role of protein phosphorylation in gene activation by hypoxia. Mammalian cells are able to sense decreased oxygen tension in their environment and turn-on the expression of specific hypoxia responsive genes. The best studied of these hypoxia regulated genes is the one that encodes for erythropoietin, the glycoproteiri hormone that regulates red cell production [1]. The response of the erythropoietin gene to hypoxia is mediated by an enhancer sequence located at the 3' flanking region of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Redox control of protein degradation

Redox biology • 2015
View 8 Excerpts
Highly Influenced

Implications of Hypoxia in Breast Cancer Metastasis to Bone

International journal of molecular sciences • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Oxygen sensing and response to hypoxia by mammalian cells.

Redox report : communications in free radical research • 1996

The role of the aryl hydrocarbon receptor nuclear translocator ( ARNT ) in hypoxic induction of gene expression

S FREDE, J FANDREY, W JELKMANN
J Biol Chem • 1996

Effect of protein kinase and phosphatase inhihitors on expression of hypoxia - inducible factor 1

DR ALESSI, A CUENDA, P COHEN, DT DUDLEY, AR SALTIEL
Biochem Biophys Res Commun • 1995

Hypoxia - inducible factor 1 is a basic - helix - loop - helix - PAS heterodimer regulated by cellular ° 2 tension

CL WANG, JIANG B-H, EA RUE, CL SEMENZA
Proc NatlAcad Sci USA • 1995

Role of protein kinasc C in hepatic erythropoietin synthesis

A KURTZ, ECKARDT K-U, +3 authors P RATCLIFFE
Exp Hematol • 1995

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

Proceedings of the National Academy of Sciences of the United States of America • 1993

Similar Papers

Loading similar papers…