Complex regulation of store-operated Ca2+ entry pathway by PKC-epsilon in vascular SMCs.

@article{Smani2008ComplexRO,
  title={Complex regulation of store-operated Ca2+ entry pathway by PKC-epsilon in vascular SMCs.},
  author={Tarik Smani and Tina J Patel and Victoria M. Bolotina},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={294 6},
  pages={C1499-508}
}
The role of PKC in the regulation of store-operated Ca2+ entry (SOCE) is rather controversial. Here, we used Ca2+-imaging, biochemical, pharmacological, and molecular techniques to test if Ca2+-independent PLA2beta (iPLA2beta), one of the transducers of the signal from depleted stores to plasma membrane channels, may be a target for the complex regulation of SOCE by PKC and diacylglycerol (DAG) in rabbit aortic smooth muscle cells (SMCs). We found that the inhibition of PKC with chelerythrine… CONTINUE READING
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