Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements.

@article{Vandenbark1996ComplexRO,
  title={Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements.},
  author={G R Vandenbark and Yidong Chen and Ellen Friday and K Pavlik and Brandi Anthony and Carlos Decastro and Russel E. Kaufman},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1996},
  volume={7 10},
  pages={1383-92}
}
The c-kit proto-oncogene is expressed in several tissues during development. To understand the mechanisms controlling the expression of this gene, we characterized the human c-kit promoter. Expression is controlled transcriptionally. The 5'-flanking DNA was used to make promoter deletion-reporter constructs that were tested in cells that were either positive or negative for endogenous c-Kit. The results demonstrate that DNA, to at least position -4100, directs transcription well in both… CONTINUE READING