Complex regulation and nuclear localization of JRK protein.

  title={Complex regulation and nuclear localization of JRK protein.},
  author={Regina Waldron and Troy Moore},
  journal={Biochemical Society transactions},
  volume={32 Pt 6},
The mouse jerky gene and its human orthologue, JRK/JH8, encode a putative DNA-binding protein with homology to the CENP-B (centromere-binding protein B). Disruption of the mouse jerky gene by transgene insertion causes generalized recurrent seizures reminiscent of human idiopathic generalized epilepsy. In addition (and similar to a cenp-b null mouse) jerky null mice exhibit postnatal weight loss and reduced fertility. Using fluorescence confocal microscopy, the cellular localization of a JRK… CONTINUE READING


Publications referenced by this paper.

Genome Res

  • K. J. Fowler, D. F. Hudson, +4 authors K. H. Choo
  • Epilepsy Res
  • 2000

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