Complex regional pain syndrome

@article{Birklein2015ComplexRP,
  title={Complex regional pain syndrome},
  author={Frank Birklein},
  journal={Journal of Neurology},
  year={2015},
  volume={252},
  pages={131-138}
}
  • F. Birklein
  • Published 1 February 2005
  • Medicine, Psychology, Biology
  • Journal of Neurology
Complex regional pain syndrome (CRPS) may develop after limb trauma and is characterized by pain, sensory-motor and autonomic symptoms. Most important for the understanding of the pathophysiology of CRPS are recent results of neurophysiological research. Major mechanism for CRPS symptoms, which might be present subsequently or in parallel during the course of CRPS, are trauma-related cytokine release, exaggerated neurogenic inflammation, sympathetically maintained pain and cortical… 
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TLDR
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References

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TLDR
This is the first time that involvement of mediators of inflammation in CRPS 1 has been so clearly and directly demonstrated and opens new approaches for the succesful use and development of immunosuppressives inCRPS 1.
Autonomic failure after stroke – is it indicative for pathophysiology of complex regional pain syndrome?
TLDR
It is suggested that many clinical symptoms and the main features of sympathetic dysfunction in CRPS could be explained by a CNS pathophysiology.
Neglect-like symptoms in complex regional pain syndrome: results of a self-administered survey.
Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand
TLDR
A bilateral disinhibition of the motor cortex in patients with complex regional pain syndrome is shown, showing a significant reduction of intracortical inhibition on both sides of patients with CRPS compared with control subjects.
The important role of neuropeptides in complex regional pain syndrome
TLDR
Increased systemic CGRP levels in patients with acute CRPS suggest neurogenic inflammation as a pathophysiologic mechanism contributing to vasodilation, edema, and increased sweating, however, pain and hyperalgesia, in particular in chronic stages, were independent of increased neuropeptide concentration.
The motor system shows adaptive changes in complex regional pain syndrome.
TLDR
The results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS.
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TLDR
Changes of the somatotopic map within the S1 cortex may depend on CRPS pain and its recovery, and these changes are unclear how these S1 changes develop following successful therapy.
Multifocal or generalized tonic dystonia of complex regional pain syndrome: A distinct clinical entity associated with HLA‐DR13
TLDR
HLA‐DR13 may be a factor indicating susceptibility to this distinct phenotype of complex regional pain syndrome, which initiated distally, involved mainly flexor muscles, and was associated with sensory and autonomic symptoms.
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