Complex regional pain syndrome: A loss of inhibition?

  title={Complex regional pain syndrome: A loss of inhibition?},
  author={F. Birklein and Wade S. Kingery},
Clinical features of post-traumatic Complex Regional Pain Syndromes (CRPS) include pain, sensory, motor and autonomic disturbances, and – in particular in the first months after the initiating trauma – signs of inflammation. These inflammatory changes do not appear to be due to a cellular-mediated immune response: Sedimentation rates, antigen titers, lymphocyte populations and blood cell counts are normal, and histological studies demonstrate little inflammatory cell infiltrate in CRPS patients… CONTINUE READING


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The association between ACE inhibitors and the complex regional pain syndrome: Suggestions for a neuro-inflammatory pathogenesis of CRPS

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