Complex osteoclastogenic inductive effects of nicotine over hydroxyapatite.

  title={Complex osteoclastogenic inductive effects of nicotine over hydroxyapatite.},
  author={Jo{\~a}o Costa-Rodrigues and Isabel Rocha and Maria Helena Fernandes},
  journal={Journal of cellular physiology},
  volume={233 2},
Cigarette smoke is associated to pathological weakening of bone tissue, being considered an important playmaker in conditions such as osteoporosis and periodontal bone loss. In addition, it is also associated with an increased risk of failure in bone regeneration strategies. The present work aimed to characterize the effects of nicotine on human osteoclastogenesis over a hydroxyapatite substrate. Osteoclast precursors were maintained in the absence or presence of the osteoclastogenesis… CONTINUE READING