Complex of Amyloid β Peptides with 24-Hydroxycholesterol and Its Effect on Hemicholinium-3 Sensitive Carriers

@article{Kritofkov2007ComplexOA,
  title={Complex of Amyloid β Peptides with 24-Hydroxycholesterol and Its Effect on Hemicholinium-3 Sensitive Carriers},
  author={Zdena Kri{\vs}tof{\'i}kov{\'a} and Vladim{\'i}r Kopeck{\'y} and Kateřina Hofbauerov{\'a} and Petra Hovorkov{\'a} and Daniela Ř{\'i}pov{\'a}},
  journal={Neurochemical Research},
  year={2007},
  volume={33},
  pages={412-421}
}
Brains of Alzheimer disease patients in early stages of dementia contain an increased 24(S)-hydroxycholesterol (cerebrosterol)/cholesterol ratio when compared to controls. In this study, effects of amyloid β peptides and of racemic 24-hydroxycholesterol were evaluated in vitro on undepleted or cholesterol-depleted hippocampal synaptosomes of young and old rats via a high-affinity choline transport and membrane anisotropy measurements. Depletion of membrane cholesterol decreased the transport of… CONTINUE READING
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