Complex multipathways alterations and oxidative stress are associated with Hailey-Hailey disease.

@article{Cialfi2010ComplexMA,
  title={Complex multipathways alterations and oxidative stress are associated with Hailey-Hailey disease.},
  author={Samantha Cialfi and Caterina Oliviero and Simona Ceccarelli and Cinzia Marchese and Luca Barbieri and Gianfranco Biolcati and Daniela Uccelletti and Claudio Palleschi and Luana Barboni and Carmelilia De Bernardo and Paola Grammatico and Armando Magrelli and Marco Salvatore and Domenica Taruscio and Luigi Frati and Alberto Gulino and Isabella Screpanti and Claudio Talora},
  journal={The British journal of dermatology},
  year={2010},
  volume={162 3},
  pages={518-26}
}
BACKGROUND Hailey-Hailey disease (HHD) is an autosomal dominant disorder characterized by suprabasal cutaneous cell separation (acantholysis) leading to the development of erosive and oozing skin lesions. While a strong relationship exists between mutations in the gene that encodes the Ca(2+)/Mn(2+)-adenosine triphosphatase ATP2C1 and HHD, we still have little understanding of how these mutations affect manifestations of the disease. OBJECTIVES This study was designed to determine early… CONTINUE READING

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