Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes

  title={Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes},
  author={John D Salamone},
  • J. Salamone
  • Published 2005
  • Psychology, Biology
  • Psychopharmacology
The suggestions that dopamine (DA) systems are involved in “motor control” and “reward” represent the classic working hypotheses on the behavioral functions of these systems. The research generated by these hypotheses has yielded results that are far more complicated than the simplest form of either hypothesis would indicate. Pharmacological or lesion-induced interference with DA function does not suppress all aspects of movement control, nor all aspects of reward, nor all aspects of motivation… 

Mesolimbic Dopamine and the Regulation of Motivated Behavior.

It has been known for some time that nucleus accumbens dopamine (DA) is involved in aspects of motivation , but theoretical approaches to understanding the functions of DA have continued to evolve

Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits

Along with prefrontal cortex and the amygdala, nucleus accumbens is a component of the brain circuitry regulating effort-related functions and may have implications for understanding drug abuse, as well as energy-related disorders such as psychomotor slowing, fatigue, or anergia in depression.

Neurobiology of Effort and the Role of Mesolimbic Dopamine

Mesolimbic dopamine is one of the brain systems mediating activational aspects of motivation and exertion of effort that integrates aspects of motivated and motor control functions involved in the instigation of action.

Nucleus Accumbens Dopamine and the Forebrain Circuitry Involved in Behavioral Activation and Effort-Related Decision Making: Implications for Understanding Anergia and Psychomotor Slowing in Depression

Evidence indicates that DA in nucleus accumbens is involved in activational aspects of motivation, and this line of research could have implications for understanding the brain circuitry involved in energy-related psychiatric disorders such as psychomotor slowing in depression, anergia, fatigue and apathy.

The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond.

Viewed from the framework of behavioral economics, the effects of accumbens DA depletions and antagonism on food-reinforced behavior are highly dependent upon the work requirements of the instrumental task, and DA-depleted rats show a heightened sensitivity to response costs, especially ratio requirements.

The Mysterious Motivational Functions of Mesolimbic Dopamine

The Aversion Function of the Limbic Dopaminergic Neurons and Their Roles in Functional Neurological Disorders

The recent advances on studies about DAergic neurons involved in aversive stimulus processing at internal conflicts are reviewed and several neural pathways, including four limbic system brain regions, which are involved in the processing of aversion are summarized.

The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation

Intra-accumbens injections of adenosine A2A agonists producing effects that are similar to those produced by accumbens DA depletion or antagonism can reverse the effects of DA D2 antagonists on effort-related choice behavior.

Behavioral Activation, Effort-Based Choice, and Elasticity of Demand for Motivational Stimuli: Basic and Translational Neuroscience Approaches

Animal procedures that assess effort-based choice have been used to characterize the behavioral functions of mesolimbic dopamine and it has been shown that interference with dopamine transmission reduces the tendency of rodents to work for food, but leaves other aspects of food motivation intact.



Influence of Dopamine on Limbic Inputs to the Nucleus Accumbens

Results from the behavioral experiments are interpreted, along with those from electrophysiological experiments, to suggest an integrated hypothesis on possible functions of dopamine in the accumbens, especially its role in behavioral response initiation.

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Findings suggest an important role of brain catecholamines in behavioral arousal, that is, in permitting animals to remain alert and to respond appropriately to relevant sensory stimuli.

Dopaminergic A10 neurones are involved in cognitive functions

It is demonstrated here that selective lesions of dopaminergic A10 neurones in the rat produce a severe and specific impairment in retention of delayed alternation.

Depletion of unilateral striatal dopamine impairs initiation of contralateral actions and not sensory attention

Two lines of evidence are presented that show that unilateral striatal DA depletion in the rat does not affect sensory attention to visual signals of reward, but rather impairs the initiation (though not the completion) of contralateral motor acts.

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The mesolimbic-mesocortical dopamine (DA) network can be considered as the Cinderella of the catecholamine family, at least by comparison with the nigrostriatal and the tuberoinfundibular pathways

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    Psychological bulletin
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It is proposed that the preexposed stimulus loses its capacity to affect behavior in conditioning, even though it predicts reinforcement, because the hippocampus inhibits the switching mechanism of the nucleus accumbens via the subiculum-accumbens pathway.