Complex maze performance in young and aged rats: response to glucose treatment and relationship to blood insulin and glucose.

@article{Long1992ComplexMP,
  title={Complex maze performance in young and aged rats: response to glucose treatment and relationship to blood insulin and glucose.},
  author={Jefferey M Long and Belinda J Davis and Paolo Garofalo and Edward L. Spangler and Donald K. Ingram},
  journal={Physiology & behavior},
  year={1992},
  volume={51 2},
  pages={411-8}
}
In aged rats and humans, impaired glucose regulation has been correlated with poor memory performance, and glucose treatment can result in improved performance. We tested this glucose hypothesis with rats in a 14-unit T-maze that has provided robust evidence of age-related performance decline. Aged (24-25 month) and young (6-7 month) male F-344 rats were pretrained for one-way active avoidance before receiving complex maze training (4 daily trials over 5 days) with the contingency of moving… CONTINUE READING

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