Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 alpha ( HNF 4 alpha ) pathways to regulate liver lipid metabolism

@inproceedings{Chen2015ComplexIB,
  title={Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 alpha ( HNF 4 alpha ) pathways to regulate liver lipid metabolism},
  author={Zhouji Chen and Matthew C. Gropler and Mayurranjan S. Mitra and Brian N Finck},
  year={2015}
}
Lipin 1 is a bifunctional protein that serves as a metabolic enzyme in the triglyceride synthesis pathway and regulates gene expression through direct protein-protein interactions with DNA-bound transcription factors in liver. Herein, we demonstrate that lipin 1 is a target gene of the hepatocyte nuclear factor 4a (HNF4a), which induces lipin 1 gene expression in cooperation with peroxisome proliferator-activated receptor c coactivator-1a (PGC-1a) through a nuclear receptor response element in… CONTINUE READING

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