Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis

@inproceedings{Peignon2011ComplexIB,
  title={Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis},
  author={Gr{\'e}gory Peignon and Aur{\'e}lie Durand and Wulfran Cacheux and Olivier Ayrault and Beno{\^i}t Terris and Pierre Laurent-Puig and Noah F Shroyer and Isabelle Van Seuningen and T. Honjo and C. Perret and B{\'e}atrice Romagnolo},
  booktitle={Gut},
  year={2011}
}
AIMS The activation of β-catenin signalling is a key step in intestinal tumorigenesis. Interplay between the β-catenin and Notch pathways during tumorigenesis has been reported, but the mechanisms involved and the role of Notch remain unclear. METHODS Notch status was analysed by studying expression of the Notch effector Hes1 and Notch ligands/receptors in human colorectal cancer (CRC) and mouse models of Apc mutation. A genetic approach was used, deleting the Apc and RBP-J or Atoh1 genes in… CONTINUE READING