Complex interchanges as a complex function of chromosome organisation.

  title={Complex interchanges as a complex function of chromosome organisation.},
  author={Yu A Eidelman and Stoitze Andreev},
  journal={Radiation protection dosimetry},
  volume={143 2-4},
A Monte Carlo technique was developed for biophysical modelling of structural organisation of 46 chromosomes within human lymphocyte interphase nucleus. The technique takes into account: different levels of chromatin organisation, non-random localisation of particular chromosomes and chromosome loci dynamics. All chromosomes in a nucleus were modelled as polymer globules. A dynamic pattern of intra/interchromosomal contacts was simulated to predict radiation-induced chromosomal exchange… CONTINUE READING

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