Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons.

@article{Fagni2000ComplexIB,
  title={Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons.},
  author={Laurent Fagni and Pascale Chavis and Fabrice Ango and Joel Bockaert},
  journal={Trends in neurosciences},
  year={2000},
  volume={23 2},
  pages={80-8}
}
Metabotropic glutamate receptors (mGluRs) can increase intracellular Ca2+ concentration via Ins(1,4,5)P3- and ryanodine-sensitive Ca2+ stores in neurons. Both types of store are coupled functionally to Ca2+-permeable channels found in the plasma membrane. The mGluR-mediated increase in intracellular Ca2+ concentration can activate Ca2+-sensitive K+ channels and Ca2+-dependent nonselective cationic channels. These mGluR-mediated effects often result from mobilization of Ca2+ from ryanodine… CONTINUE READING
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