Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets.

@article{Comtesse2005ComplexHI,
  title={Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets.},
  author={Nicole Comtesse and Andrea Zippel and Sascha Walle and Dominik Monz and Christina Backes and Ulrike Fischer and Jens Mayer and Nicole Ludwig and Andreas Hildebrandt and Andreas Keller and Wolf-Ingo Steudel and Hans-Peter Lenhof and Eckart Meese},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 27},
  pages={9601-6}
}
There are numerous studies on the immune response against malignant human tumors. This study was aimed to address the complexity and specificity of humoral immune response against a benign human tumor. We assembled a panel of 62 meningioma-expressed antigens that show reactivity with serum antibodies of meningioma patients, including 41 previously uncharacterized antigens by screening of a fetal brain expression library. We tested the panel for reactivity with 48 sera, including sera of… CONTINUE READING
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