Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation

@article{Lautier2003ComplexHO,
  title={Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation},
  author={Corinne Lautier and Samira Ait El Mkadem and Eric Renard and Jean Fr{\'e}d{\'e}ric Brun and Jean Christophe Gris and Jacques Bringer and Florin Grigorescu},
  journal={Human Genetics},
  year={2003},
  volume={113},
  pages={34-43}
}
In order to understand the role of the insulin receptor substrate-2 (IRS2) gene (chromosome region: 13q34) in obesity, a complex disorder associated with insulin resistance and glucose intolerance, we determined single nucleotide polymorphims (SNPs) and complex haplotypes in women with morbid obesity and a body mass index (BMI) of 41±0.8 kg/m2 (n=99… CONTINUE READING