Complex genetics of amyotrophic lateral sclerosis.

@article{Kunst2004ComplexGO,
  title={Complex genetics of amyotrophic lateral sclerosis.},
  author={Catherine B. Kunst},
  journal={American journal of human genetics},
  year={2004},
  volume={75 6},
  pages={933-47}
}
Amyotrophic lateral sclerosis (ALS) is a common adultonset neurodegenerative disease leading to paralysis and death typically within 2–5 years of diagnosis. Approximately 10% of ALS cases are inherited, with the remainder of cases being sporadic in origin. This distribution of familial and sporadic disease is similar to other adult-onset neurodegenerative diseases, such as Parkinson disease and Alzheimer disease (see, e.g., Przedborski et al. 2003). The annual incidence of ALS is 1–2 per 100… CONTINUE READING

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This distribution of familial and sporadic disease is similar to other adult - onset neurodegenerative diseases , such as Parkinson disease and Alzheimer disease ( see , e.g. , Przedborski et al .
This distribution of familial and sporadic disease is similar to other adult - onset neurodegenerative diseases , such as Parkinson disease and Alzheimer disease ( see , e.g. , Przedborski et al .
Amyotrophic lateral sclerosis ( ALS ) is a common adultonset neurodegenerative disease leading to paralysis and death typically within 2–5 years of diagnosis .
Amyotrophic lateral sclerosis ( ALS ) is a common adultonset neurodegenerative disease leading to paralysis and death typically within 2–5 years of diagnosis .
Amyotrophic lateral sclerosis ( ALS ) is a common adultonset neurodegenerative disease leading to paralysis and death typically within 2–5 years of diagnosis .
Amyotrophic lateral sclerosis ( ALS ) is a common adultonset neurodegenerative disease leading to paralysis and death typically within 2–5 years of diagnosis .
Interestingly , Onuf ’s nucleus , which controls urethral and sphincter function , and motor neurons in the oculomotor , trochlear , and abducens cranial nerve nuclei are spared .
Interestingly , Onuf ’s nucleus , which controls urethral and sphincter function , and motor neurons in the oculomotor , trochlear , and abducens cranial nerve nuclei are spared .
It is thought that the process of ALS begins with an initiation or triggering event , followed by the propagation of motor neuron demise up and down the spinal cord ( see Armon [ 2003 ] for a detailed description of this hypothesis ) .
This distribution of familial and sporadic disease is similar to other adult - onset neurodegenerative diseases , such as Parkinson disease and Alzheimer disease ( see , e.g. , Przedborski et al .
It is thought that the process of ALS begins with an initiation or triggering event , followed by the propagation of motor neuron demise up and down the spinal cord ( see Armon [ 2003 ] for a detailed description of this hypothesis ) .
This distribution of familial and sporadic disease is similar to other adult - onset neurodegenerative diseases , such as Parkinson disease and Alzheimer disease ( see , e.g. , Przedborski et al .
This distribution of familial and sporadic disease is similar to other adult - onset neurodegenerative diseases , such as Parkinson disease and Alzheimer disease ( see , e.g. , Przedborski et al .
This distribution of familial and sporadic disease is similar to other adult - onset neurodegenerative diseases , such as Parkinson disease and Alzheimer disease ( see , e.g. , Przedborski et al .
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