Complex genetics and the etiology of human congenital heart disease.

@article{Gelb2014ComplexGA,
  title={Complex genetics and the etiology of human congenital heart disease.},
  author={Bruce D Gelb and Wendy K Chung},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2014},
  volume={4 7},
  pages={a013953}
}
Congenital heart disease (CHD) is the most common birth defect. Despite considerable advances in care, CHD remains a major contributor to newborn mortality and is associated with substantial morbidities and premature death. Genetic abnormalities appear to be the primary cause of CHD, but identifying precise defects has proven challenging, principally because CHD is a complex genetic trait. Mainly because of recent advances in genomic technology such as next-generation DNA sequencing, scientists… CONTINUE READING
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