Complex genetic origin of Indian populations and its implications

@article{Tamang2012ComplexGO,
  title={Complex genetic origin of Indian populations and its implications},
  author={Rakesh Tamang and Lalji Singh and Kumarasamy Thangaraj},
  journal={Journal of Biosciences},
  year={2012},
  volume={37},
  pages={911-919}
}
Indian populations are classified into various caste, tribe and religious groups, which altogether makes them very unique compared to rest of the world. The long-term firm socio-religious boundaries and the strict endogamy practices along with the evolutionary forces have further supplemented the existing high-level diversity. As a result, drawing definite conclusions on its overall origin, affinity, health and disease conditions become even more sophisticated than was thought earlier. In spite… 
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References

SHOWING 1-10 OF 87 REFERENCES
Genetic evidence on the origins of Indian caste populations.
TLDR
It is concluded that Indian castes are most likely to be of proto-Asian origin with West Eurasian admixture resulting in rank-related and sex-specific differences in the genetic affinities of castes to Asians and Europeans.
Diverse genetic origin of Indian Muslims: evidence from autosomal STR loci
TLDR
The study reveals that the spread of Islamic faith in the Indian subcontinent was predominantly cultural transformation associated with minor gene flow from West Asia.
Peopling of South Asia: investigating the caste-tribe continuum in India.
TLDR
This review attempts to summarize recent genetic studies on Indian caste and tribal populations with the focus on the information embedded in the socially defined structure of Indian populations.
Genetic variation in India.
TLDR
Three distinct surveys reported here indicate that geographic proximity, ethnohistory, and biosocial and cultural affiliation are important determinants of genetic affinity in populations of India.
A prehistory of Indian Y chromosomes: evaluating demic diffusion scenarios.
TLDR
The Y-chromosomal data consistently suggest a largely South Asian origin for Indian caste communities and therefore argue against any major influx, from regions north and west of India, of people associated either with the development of agriculture or the spread of the Indo-Aryan language family.
Genetic Affinities of the Central Indian Tribal Populations
TLDR
The results obtained by haploid as well as diploid genetic markers revealed strong genetic affinity of Bharia (a Dravidian speaking tribe) with the Austroasiatic (Munda) group.
The Influence of Natural Barriers in Shaping the Genetic Structure of Maharashtra Populations
TLDR
The analysis suggests that Indian populations, including Maharashtra state, are largely derived from Paleolithic ancient settlers; however, a more recent (∼10 Ky older) detectable paternal gene flow from west Asia is well reflected in the present study.
Indian Siddis: African descendants with Indian admixture.
TLDR
A genome-wide survey of the Siddis shows that they have inherited ancestry from Africans, Indians, and possibly Europeans (Portuguese), and analyses of the uniparental (Y-chromosomal and mitochondrial DNA) markers indicate that the Siddi trace their ancestry to Bantu speakers from sub-Saharan Africa.
The genetic heritage of the earliest settlers persists both in Indian tribal and caste populations.
TLDR
Results show that Indian tribal and caste populations derive largely from the same genetic heritage of Pleistocene southern and western Asians and have received limited gene flow from external regions since the Holocene.
Phylogeography of mtDNA haplogroup R7 in the Indian peninsula
TLDR
Among Indo-Europeans, and particularly in Dravidians, the haplogroup is, despite its lower frequency, phylogenetically more divergent, while among the Munda speakers only one sub-clade of R7, i.e. R7a1, can be observed.
...
1
2
3
4
5
...