Complex formation of Plk1 and INCENP required for metaphase–anaphase transition

Abstract

Mitotic chromosomal dynamics is regulated by the coordinated activities of many mitotic kinases, such as cyclin-dependent kinase 1 (Cdk1), Aurora-B or Polo-like kinase 1 (Plk1), but the mechanisms of their coordination remain unknown. Here, we report that Cdk1 phosphorylates Thr 59 and Thr 388 on inner centromere protein (INCENP), which regulates the… (More)
DOI: 10.1038/ncb1350

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@article{Goto2006ComplexFO, title={Complex formation of Plk1 and INCENP required for metaphase–anaphase transition}, author={Hidemasa Goto and Tohru Kiyono and Yasuko Tomono and Aie Kawajiri and Takeshi Urano and Koichi Furukawa and Erich A. Nigg and Masaki Inagaki}, journal={Nature Cell Biology}, year={2006}, volume={8}, pages={180-187} }