Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA.

@article{Miller1997ComplexFB,
  title={Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA.},
  author={Shelley D. Miller and Kelvin A. Moses and Lata Jayaraman and Carol Prives},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 4},
  pages={2194-201}
}
Human replication protein A (RP-A) (also known as human single-stranded DNA binding protein, or HSSB) is a multisubunit complex involved in both DNA replication and repair. Potentially important to both these functions, it is also capable of complex formation with the tumor suppressor protein p53. Here we show that although p53 is unable to prevent RP-A from associating with a range of single-stranded DNAs in solution, RP-A is able to strongly inhibit p53 from functioning as a sequence-specific… CONTINUE READING

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