Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis.

@article{Herath2012ComplexEP,
  title={Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis.},
  author={Nirmitha I. Herath and Mark Damien Spanevello and James D Doecke and Fiona M. Smith and Celio Pouponnot and Andrew W. Boyd},
  journal={European journal of cancer},
  year={2012},
  volume={48 5},
  pages={753-62}
}
Aberrant expression of Eph and ephrin proteins in human cancers is extensively documented. However, data are frequently limited to one gene and therefore incomplete and in some instances conflicting. We analysed expression of all Eph and ephrin genes in colorectal cancer (CRC) cell lines and 153 clinical specimens, providing for the first time a comprehensive analysis of this system in CRC. Eph/ephrin mRNA expression was assessed by quantitative real-time PCR and correlated with protein… CONTINUE READING
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