Complex expression pattern of Wnt ligands and frizzled receptors in human placenta and its trophoblast subtypes.

@article{Sonderegger2007ComplexEP,
  title={Complex expression pattern of Wnt ligands and frizzled receptors in human placenta and its trophoblast subtypes.},
  author={Stefan Sonderegger and Heinrich Husslein and Christina Leisser and Martin Kn{\"o}fler},
  journal={Placenta},
  year={2007},
  volume={28 Suppl A},
  pages={S97-102}
}
Canonical Wingless (Wnt) signalling provoked by exogenous and endogenous Wnt ligands was recently shown to play a crucial role in the invasive differentiation of human trophoblasts. To gain insights into the expression pattern of the developmental regulators, we analysed all human Wnt ligands and their frizzled (FZD) receptors in the human placenta and different trophoblast model systems using semi-quantitative PCR. Fourteen out of 19 Wnt ligands and 8 out of 10 FZD receptors were detectable in… CONTINUE READING

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