Complex estrogenic regulation of catechol-O-methyltransferase (COMT) in rats.

@article{Schendzielorz2011ComplexER,
  title={Complex estrogenic regulation of catechol-O-methyltransferase (COMT) in rats.},
  author={Nadia Schendzielorz and A Rysa and I Reenila and Atso Raasmaja and P. T. Mannisto},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2011},
  volume={62 4},
  pages={483-90}
}
Catechol-O-methyltransferase (COMT) activity depends on gender, age and physiological status suggesting that estrogen may regulate COMT activity. In fact, estrogens down-regulate the function of COMT promoters in cell cultures. On the other hand, COMT may play an important role in estrogen-induced cancers due to its ability to inactivate estrogen metabolites and thereby lowering the levels of these potential carcinogens. In this study, we explored the effect of estrogen on COMT activity in vivo… CONTINUE READING

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