Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory.

@article{Savonenko2003ComplexEO,
  title={Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory.},
  author={Alena V. Savonenko and Tomasz Werka and Evgeni Nikolaev and Kazimierz Zielinski and Leszek Kaczmarek},
  journal={Learning & memory},
  year={2003},
  volume={10 4},
  pages={293-303}
}
Although much has been learned about the role of the amygdala in Pavlovian fear conditioning, relatively little is known about an involvement of this structure in more complex aversive learning, such as acquisition of an active avoidance reaction. In the present study, rats with a pretraining injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, 2-amino-5-phosphonopentanoic acid (APV), into the basolateral amygdala (BLA) were found to be impaired in two-way active avoidance learning… CONTINUE READING

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