Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid.

@article{Sarmah2013ComplexCD,
  title={Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: prevention with folic acid.},
  author={Swapnalee Sarmah and James A Marrs},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2013},
  volume={242 10},
  pages={
          1184-201
        }
}
BACKGROUND Fetal alcohol spectrum disorder (FASD) describes a range of birth defects including various congenital heart defects (CHDs). Mechanisms of FASD-associated CHDs are not understood. Whether alcohol interferes with a single critical event or with multiple events in heart formation is not known. RESULTS Our zebrafish embryo experiments showed that ethanol interrupts different cardiac regulatory networks and perturbs multiple steps of cardiogenesis (specification, myocardial migration… CONTINUE READING
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