Complex association of protein C gene promoter polymorphism with circulating protein C levels and thrombotic risk.

@article{Aiach1999ComplexAO,
  title={Complex association of protein C gene promoter polymorphism with circulating protein C levels and thrombotic risk.},
  author={Martine Aiach and Viviane Nicaud and Martine Alhenc-Gelas and Sophie Gandrille and Eric Arnaud and Jean Amiral and Louis Guize and Jean-noel Fiessinger and Joseph Emmerich},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 6},
  pages={1573-6}
}
The allele and haplotype frequency of the -1654 C/T and -1641 A/G protein C (PC) gene promoter polymorphisms was determined and analyzed according to circulating PC concentrations in 394 healthy subjects aged 20 to 60 years. The CG haplotype was associated with a lower PC concentration in both homozygous and heterozygous subjects compared with noncarriers. The TA allele had the reverse effect, but only in homozygotes. The distribution of the CG and TA alleles was significantly different in 242… CONTINUE READING
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