Complex and extensive post-transcriptional regulation revealed by integrative proteomic and transcriptomic analysis of metabolite stress response in Clostridium acetobutylicum

@inproceedings{Venkataramanan2015ComplexAE,
  title={Complex and extensive post-transcriptional regulation revealed by integrative proteomic and transcriptomic analysis of metabolite stress response in Clostridium acetobutylicum},
  author={Keerthi Venkataramanan and Lie Min and Shuyu Hou and Shawn William Jones and Matthew T. Ralston and Kelvin H. Lee and Eleftherios T. Papoutsakis},
  booktitle={Biotechnology for Biofuels},
  year={2015}
}
BackgroundClostridium acetobutylicum is a model organism for both clostridial biology and solvent production. The organism is exposed to its own toxic metabolites butyrate and butanol, which trigger an adaptive stress response. Integrative analysis of proteomic and RNAseq data may provide novel insights into post-transcriptional regulation.ResultsThe identified iTRAQ-based quantitative stress proteome is made up of 616 proteins with a 15 % genome coverage. The differentially expressed proteome… CONTINUE READING
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