Complex Selection on Human Polyadenylation Signals Revealed by Polymorphism and Divergence Data

@inproceedings{Kainov2016ComplexSO,
  title={Complex Selection on Human Polyadenylation Signals Revealed by Polymorphism and Divergence Data},
  author={Yaroslav A. Kainov and Vasily N. Aushev and Sergey A. Naumenko and Elena M. Tchevkina and Georgii A. Bazykin},
  booktitle={Genome biology and evolution},
  year={2016}
}
Polyadenylation is a step of mRNA processing which is crucial for its expression and stability. The major polyadenylation signal (PAS) represents a nucleotide hexamer that adheres to the AATAAA consensus sequence. Over a half of human genes have multiple cleavage and polyadenylation sites, resulting in a great diversity of transcripts differing in function, stability, and translational activity. Here, we use available whole-genome human polymorphism data together with data on interspecies… CONTINUE READING
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