Complex Regional Pain Syndrome: A Comprehensive Review

  title={Complex Regional Pain Syndrome: A Comprehensive Review},
  author={Samantha Taylor and Nazir Noor and Ivan Urits and Antonella Paladini and Monica Sri Sadhu and Clay Gibb and T. Ingebretsen Carlson and Dariusz Myrcik and Giustino Varrassi and Omar Viswanath},
  journal={Pain and Therapy},
  pages={875 - 892}
Complex regional pain syndrome (CRPS) is a chronic pain condition often involving hyperalgesia and allodynia of the extremities. CRPS is divided into CRPS-I and CRPS-II. Type I occurs when there is no confirmed nerve injury. Type II is when there is known associated nerve injury. Female gender is a risk factor for developing CRPS. Other risk factors include fibromyalgia and rheumatoid arthritis. Unfortunately, the pathogenesis of CRPS is not yet clarified. Some studies have demonstrated… 

Complex regional pain syndrome: Literature review as a guide for the practicing clinician

Complex regional pain syndrome (CRPS) is a chronic complex disorder that significantly affects the quality of life of the people suffering from it. This syndrome affects the extremities after trauma

How to Treat Algodystrophy and Rheumatic Comorbidity in Myelofibrosis: Three Case Reports

As overlapping interactions and clinical manifestations between hematologic neoplasms and rheumatologic diseases exist, new clinical manifestations, such as algodystrophy, may emerge during myelofibrosis and need to be monitored in the long term by a multidisciplinary team.

An Algorithm for Elective Amputation Combined with Targeted Muscle Reinnervation in Complex Regional Pain Syndrome—A Perspective

An advanced algorithm for amputation indications in CRPS patients combining all new factors is proposed, which consists of extensive pre-operative psychiatric assessment, diagnostic hybrid prosthetic fitting, fMRI analyses, multidisciplinary board advice as well as targeted muscle reinnervation and amputation procedures with final prosthetics fitting and rehabilitation.

Post-traumatic and non-traumatic Complex Regional Pain Syndrome type I

To prevent severe and disabling consequences, international guidelines suggest a prompt multimodal approach to algodystrophy, including pharmacological (bisphosphonates, particularly neridronate) and non-pharmacological (i.e., rehabilitation interventions) measures.

A randomized, controlled trial on the effectiveness of a proprietary marine lipo-peptide formula vs omega-3 on cytokines profile, anxiety, and pain symptoms in patients with fibromyalgia

These results provide the first indications that the LD-1227 treatment has a statistically significant effect on the recognized fibromyalgia diagnosis metrics of WPI, TTP, and SSS as well on inflammatory markers and parasympathetic balance.

Feasibility Study of Pain Assessment by using Thermography

The use of the active thermography is proposed to analyse the neurogenic inflammatory response which characterizes nociceptive pain and results have shown the potentiality of thermography to be a screening biomarker of the mechanism responsible of the abnormalities in sympathetic nervous system due to pain.

The place of gabapentinoids in providing specialized care to patients with mental and behavioral disorders according to the principles of evidence-based medicine (literature review)

Drawing conclusions are drawn that the use of gabapentinoids to persons with mental and behavioral disorders are not for their intended purpose, and therefore the appointment of gapapentinoid is not recommended for providing specialized care to patients as monotherapy, the question of the effectiveness of combi- nation therapy remains open.

An Advanced Practice Provider Guide to Peripheral Nerve Stimulation

An APP guide to PNS is devised based on an in-depth search of multiple databases for studies on neuromodulation, pain management, and APPs and outlined ways in which APPs can optimize the care of PNS patients and how the skillset of the APP in a PNS practice can potentially improve patient outcomes.

Current understanding of complex regional pain syndrome

Issues of interventional methods for the treatment of CRPS, including sympathetic blocks and various ablation techniques under ultrasound and fluoroscopic guidance, and a new waveform for spinal cord stimulation and new stimulation targets such as dorsal root ganglia have been proposed.



A medical mystery of complex regional pain syndrome

Molecular Aspects of Regional Pain Syndrome

The pathophysiological mechanisms underlying CRPS involve both inflammatory and neurological pathways and vagal nerve stimulation might have the potential for treating CRPS through the cholinergic anti-inflammatory pathway.

Complex Regional Pain Syndrome: An update

This syndrome develops in two phases, the acute (warm) phase, with the classic symptoms of inflammation, and the chronic phase, often characterized by trophic changes of the soft tissues and even bones, which is the dominating feature.

Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II.

There was a paucity of high quality evidence concerning physiotherapy treatment for pain and disability in people with CRPS I and II and very low quality evidence that graded motor imagery (GMI) may be useful for improving pain.

Pediatric complex regional pain syndrome: a review

Standard care consists of a multidisciplinary approach with the implementation of intensive physical therapy in conjunction with psychological counseling, and Pharmacological treatments may aid in reducing pain in order to allow the patient to participate fully in intensive physiotherapy.

Autoinflammatory and autoimmune contributions to complex regional pain syndrome

Evidence for dysfunction of both the innate and adaptive immune systems in CRPS is presented and therapeutic interventions could be designed targeting autoinflammation, autoimmunity, or the neural support for these phenomena.

Subcutaneous Botulinum Toxin A for the Treatment of Refractory Complex Regional Pain Syndrome

Complex Regional Pain Syndrome After Distal Radius Fracture Is Uncommon and Is Often Associated With Fibromyalgia

A coded diagnosis of CPRS is uncommonly applied to patients on the higher range of pain, stiffness, and limitations after fracture of the distal radius—most commonly in women and in association with another nonspecific, objectively unverifiable diagnosis (fibromyalgia)—and that this label may lead to more testing and invasive treatment.

Pathophysiological Mechanisms Involved in Vasomotor Disturbances in Complex Regional Pain Syndrome and Implications for Therapy: A Review

Diagnostic tools to distinguish the underlying pathophysiological mechanisms of vasomotor disturbances would enable a mechanism‐based treatment and improve clinical outcome in cold CRPS.

Signs and Symptoms in 1,043 Patients with Complex Regional Pain Syndrome.

  • S. OttC. Maihöfner
  • Medicine, Psychology
    The journal of pain : official journal of the American Pain Society
  • 2018