Complex Interplay between the Lipin 1 and the Hepatocyte Nuclear Factor 4 α (HNF4α) Pathways to Regulate Liver Lipid Metabolism

@article{Chen2012ComplexIB,
  title={Complex Interplay between the Lipin 1 and the Hepatocyte Nuclear Factor 4 $\alpha$ (HNF4$\alpha$) Pathways to Regulate Liver Lipid Metabolism},
  author={Z. Chen and Matthew C. Gropler and Mayurranjan S. Mitra and B. Finck},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
Lipin 1 is a bifunctional protein that serves as a metabolic enzyme in the triglyceride synthesis pathway and regulates gene expression through direct protein-protein interactions with DNA-bound transcription factors in liver. Herein, we demonstrate that lipin 1 is a target gene of the hepatocyte nuclear factor 4α (HNF4α), which induces lipin 1 gene expression in cooperation with peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) through a nuclear receptor response element in… Expand
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  • G. Schweitzer, S. Collier, +10 authors B. Finck
  • Chemistry, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2019
Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling.
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