Complex I is rate-limiting for oxygen consumption in the nerve terminal.

@article{Telford2009ComplexII,
  title={Complex I is rate-limiting for oxygen consumption in the nerve terminal.},
  author={Jayne E Telford and Se{\'a}n M. Kilbride and Gavin P. Davey},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 14},
  pages={9109-14}
}
Metabolic control analysis was used to determine the spread of control exerted by the electron transport chain complexes over oxygen consumption rates in the nerve terminal. Oxygen consumption rates and electron transport chain complex activities were titrated with appropriate inhibitors to determine the flux control coefficients and the inhibition thresholds in rat brain synaptosomes. The flux control coefficients for complex I, complex II/III, complex III, and complex IV were found to be 0.30… CONTINUE READING