Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels.

@article{Lustgarten2012ComplexIG,
  title={Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels.},
  author={Michael S. Lustgarten and Arunabh Bhattacharya and Florian L. Muller and Youngmok Charles Jang and Takahiko Shimizu and Takuji Shirasawa and Arlan Richardson and Holly van Remmen},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={422 3},
  pages={515-21}
}
Mitochondrial complex I has previously been shown to release superoxide exclusively towards the mitochondrial matrix, whereas complex III releases superoxide to both the matrix and the cytosol. Superoxide produced at complex III has been shown to exit the mitochondria through voltage dependent anion channels (VDAC). To test whether complex I-derived, mitochondrial matrix-directed superoxide can be released to the cytosol, we measured superoxide generation in mitochondria isolated from wild type… CONTINUE READING

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