Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death.

  title={Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death.},
  author={Matthew B Reeves and Andrew Davies and Brian Patrick McSharry and Gavin W G Wilkinson and John H. Sinclair},
  volume={316 5829},
Human cytomegalovirus infection perturbs multiple cellular processes that could promote the release of proapoptotic stimuli. Consequently, it encodes mechanisms to prevent cell death during infection. Using rotenone, a potent inhibitor of the mitochondrial enzyme complex I (reduced nicotinamide adenine dinucleotide-ubiquinone oxido-reductase), we found that human cytomegalovirus infection protected cells from rotenone-induced apoptosis, a protection mediated by a 2.7-kilobase virally encoded… CONTINUE READING


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