Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.

  title={Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.},
  author={Emmanuel Jean-Marie Mignot and L. Lin and William Rogers and Yutaka Honda and Xiaowen Qiu and X. Lin and Michele L. Okun and Hirohiko Hohjoh and Tetsuro Miki and Susan H Hsu and Mary S. Leffell and F. Carl Grumet and Marcelo A. Fernandez-Vina and Makoto Honda and Neil Risch},
  journal={American journal of human genetics},
  volume={68 3},
Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1*0602. Few studies have investigated the influence that additional HLA class II alleles have on susceptibility to this disease. In this work, 1,087 control subjects and 420 narcoleptic subjects with cataplexy, from three ethnic groups, were HLA typed, and the effects of HLA-DRB1, -DQA1, and -DQB1 were analyzed. As reported elsewhere, almost all… 

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