Complex Drug-Drug-Disease Interactions Between Amiodarone, Warfarin, and the Thyroid Gland

@article{Kurnik2004ComplexDI,
  title={Complex Drug-Drug-Disease Interactions Between Amiodarone, Warfarin, and the Thyroid Gland},
  author={Daniel Kurnik and Ronen Loebstein and Zvi Farfel and David Ezra and Hillel Halkin and David Olchovsky},
  journal={Medicine},
  year={2004},
  volume={83},
  pages={107-113}
}
Abstract: Many patients with cardiac arrhythmias require concomitant therapy with warfarin and amiodarone. Beyond the predictable pharmacokinetic drug-drug interaction requiring a significant warfarin dose reduction, the iodine-rich amiodarone affects the thyroid gland, causing overt hypothyroidism or thyrotoxicosis in 14%-18% of cases. In turn, thyroid disorders may affect warfarin sensitivity, with hypothyroidism and thyrotoxicosis resulting in increased or decreased warfarin requirements… 
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TLDR
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TLDR
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