Complex Carbohydrates Are Not Removed During Processing of Glycoproteins by Dendritic Cells

@article{Vlad2002ComplexCA,
  title={Complex Carbohydrates Are Not Removed During Processing of Glycoproteins by Dendritic Cells},
  author={Anda M. Vlad and Stefan C. Muller and Mare Cudic and H. U. Paulsen and Laszlo Otvos and Franz-Georg Hanisch and Olivera Olja J Finn},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={196},
  pages={1435 - 1446}
}
In contrast to protein antigens, processing of glycoproteins by dendritic cells (DCs) for presentation to T cells has not been well studied. We developed mouse T cell hybridomas to study processing and presentation of the tumor antigen MUC1 as a model glycoprotein. MUC1 is expressed on the surface as well as secreted by human adenocarcinomas. Circulating soluble MUC1 is available for uptake, processing, and presentation by DCs in vivo and better understanding of how that process functions in… CONTINUE READING