Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.


Germinal center (GC) B cells evolve toward increased affinity by a Darwinian process that has been studied primarily in genetically restricted, hapten-specific responses. We explored the population dynamics of genetically diverse GC responses to two complex antigens-Bacillus anthracis protective antigen and influenza hemagglutinin-in which B cells competed… (More)
DOI: 10.1016/j.immuni.2016.02.010


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