Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes

@article{Ramazzina2006CompletingTU,
  title={Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes},
  author={Ileana Ramazzina and C. Folli and A. Secchi and R. Berni and R. Percudani},
  journal={Nature Chemical Biology},
  year={2006},
  volume={2},
  pages={144-148}
}
  • Ileana Ramazzina, C. Folli, +2 authors R. Percudani
  • Published 2006
  • Biology, Medicine
  • Nature Chemical Biology
  • Mammals that degrade uric acid are not affected by gout or urate kidney stones. It is not fully understood how they convert uric acid into the much more soluble allantoin. Until recently, it had long been thought that urate oxidase was the only enzyme responsible for this conversion1,2. However, detailed studies of the mechanism and regiochemistry of urate oxidation3,4,5 have called this assumption into question, suggesting the existence of other distinct enzymatic activities. Through… CONTINUE READING
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