Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes

  title={Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes},
  author={Ileana Ramazzina and C. Folli and A. Secchi and R. Berni and R. Percudani},
  journal={Nature Chemical Biology},
  • Ileana Ramazzina, C. Folli, +2 authors R. Percudani
  • Published 2006
  • Biology, Medicine
  • Nature Chemical Biology
  • Mammals that degrade uric acid are not affected by gout or urate kidney stones. It is not fully understood how they convert uric acid into the much more soluble allantoin. Until recently, it had long been thought that urate oxidase was the only enzyme responsible for this conversion1,2. However, detailed studies of the mechanism and regiochemistry of urate oxidation3,4,5 have called this assumption into question, suggesting the existence of other distinct enzymatic activities. Through… CONTINUE READING
    160 Citations
    Evolutionary history and metabolic insights of ancient mammalian uricases
    • 156
    • PDF
    Identification of a Formate-Dependent Uric Acid Degradation Pathway in Escherichia coli.
    • 3
    • PDF
    Mouse transthyretin-related protein is a hydrolase which degrades 5-hydroxyisourate, the end product of the uricase reaction.
    • 19
    Characterization of the Complete Uric Acid Degradation Pathway in the Fungal Pathogen Cryptococcus neoformans
    • 31
    • PDF
    Walking on the ureide pathway
    • 1
    • Highly Influenced
    • PDF


    Evolution of urate-degrading enzymes in animal peroxisomes
    • 56
    Transthyretin‐related proteins function to facilitate the hydrolysis of 5‐hydroxyisourate, the end product of the uricase reaction
    • 62
    Identification of the True Product of the Urate Oxidase Reaction
    • 103
    Mechanism of uricase action.
    • 26
    Identification and Purification of Hydroxyisourate Hydrolase, a Novel Ureide-metabolizing Enzyme*
    • 45
    • PDF
    Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation.
    • 251
    Spectroscopic characterization of intermediates in the urate oxidase reaction.
    • 91
    Loss of urate oxidase activity in hominoids and its evolutionary implications.
    • 317
    • PDF
    The transthyretin-related protein family.
    • 71
    • PDF