Complete transposition requires four active monomers in the mu transposase tetramer.

@article{Baker1994CompleteTR,
  title={Complete transposition requires four active monomers in the mu transposase tetramer.},
  author={Tania A. Baker and E Kremenstova and Lusong Luo},
  journal={Genes & development},
  year={1994},
  volume={8 20},
  pages={2416-28}
}
A tetramer of Mu transposase (MuA) cleaves and joins multiple DNA strands to promote transposition. Derivatives of MuA altered at two acidic residues that are conserved among transposases and retroviral integrases form tetramers but are defective in both cleavage and joining. These mutant proteins were used to analyze the contribution of individual monomers to the activity of the tetramer. The performance of different protein combinations demonstrates that not all monomers need to be… CONTINUE READING

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Polynucleotidyl transfer reaction in trans ­ positional DNA recombination

  • K. Mizuuchi
  • / . Virol .

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