Complete switch to everolimus in long-term kidney transplants: evolution of the renal function.

Abstract

INTRODUCTION The use of M-tor inhibitors plus withdrawal of anticalcineurins after 3 months of posttransplantation is usually linked to improvements in renal function. The long-term effects of substitution of anticalcineurinis by everolimus remain unknown. The aim in this study was to evaluate the evolution of renal function and the proteinuria after a complete switch of long-term functioning allograft patients to everolimus. We treated 30 renal transplanted patients with everolimus, at a mean time posttransplantation of 123.8 +/- 74.2 months. The 27 patients, including 17 treated with tacrolimus and 10 with cyclosporine, who were controlled for at least 6 months were included in this study. Seventeen of them were diagnosed to display chronic allograft nephropathy (CAN). RESULTS The patients with CAN showed a basal creatinine of 1.81 +/- 0.4; with after a year, 1.61 +/- 0.38; and after 2 years, 1.56 +/- 0.49 mg/dL (P < .05). No significant changes were observed among patients without CAN: 1.1 +/- 0.32, 0.97 +/- 0.15, and 0.97 +/- 0.15 mg/dL, respectively. In CAN patients, the protein/creatinine quotient was: basal = 0.30 +/- 0.13, one year = 0.63 +/- 0.68, and 2 years = 0.48 +/- 0.34. In the other patients the values were 0.2 +/- 0.07, 0.73 +/- 0.7, and 0.32 +/- 0.17, respectively, after a late switch to everolimus. CONCLUSION The improved renal function occurred mainly in patients with CAN. Patients who did not suffer from it showed a greater rise in proteinuria. Nevertheless, both groups experienced decreased proteinuria after 2 years.

DOI: 10.1016/j.transproceed.2009.06.162

Cite this paper

@article{Fernndez2009CompleteST, title={Complete switch to everolimus in long-term kidney transplants: evolution of the renal function.}, author={Ana Fern{\'a}ndez and Roberto Marc{\'e}n and Cristina Galeano and Silvia Cald{\'e}s and Yesika Mar{\'i}a Amezquita and Juan Jos{\'e} Villafruela and Julio Pascual and Jos{\'e} Burgos and Nuria Rodr{\'i}guez-Mendiola and Joaqu{\'i}n A. Ortu{\~n}o}, journal={Transplantation proceedings}, year={2009}, volume={41 6}, pages={2345-7} }