Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.

@article{Grech2000CompleteSC,
  title={Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.},
  author={Adrian P. Grech and Richard Quinn and Deepak Kumar Srinivasan and X Badoux and Robert Brink},
  journal={Molecular immunology},
  year={2000},
  volume={37 12-13},
  pages={721-34}
}
The complete murine TRAF2 gene was obtained using a lambda phage and PCR cloning strategy. The gene was found to consist of ten coding and one 5' non-coding exon spread over 28 kbp of DNA. We also report the basic structure of the human TRAF5 and TRAF6 genes obtained by analysis of the genomic DNA database. Comparison of these three gene structures, along with those previously described for TRAF1, TRAF3 and TRAF4, revealed the evolutionary relationship between the six known mammalian TRAFs. The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

NF-κB: where did it come from and why?

Immunological reviews • 2012
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…