Complete sequences of glucagon-like peptide-1 from human and pig small intestine.

  title={Complete sequences of glucagon-like peptide-1 from human and pig small intestine.},
  author={Cathrine Orskov and Michele Bersani and Anders Johnsen and Peter H\ojrup and J. J. Holst},
  journal={The Journal of biological chemistry},
  volume={264 22},
In the small intestine, proglucagon is processed into the previously characterized peptide "glicentin" (proglucagon (PG) 1-69) and two smaller peptides showing about 50% homology with glucagon: glucagon-like peptide-1 and -2. It was assumed that the sites of post-translational cleavage in the small intestine of the proglucagon precursor were determined by pairs of basic amino acid residues flanking the two peptides. Earlier studies have shown that synthetic glucagon-like peptide-1 (GLP-1… CONTINUE READING
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