Corpus ID: 25667403

Complete sequences of glucagon-like peptide-1 from human and pig small intestine.

@article{Orskov1989CompleteSO,
  title={Complete sequences of glucagon-like peptide-1 from human and pig small intestine.},
  author={C. Orskov and M. Bersani and A. Johnsen and P. H{\o}jrup and J. Holst},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 22},
  pages={
          12826-9
        }
}
  • C. Orskov, M. Bersani, +2 authors J. Holst
  • Published 1989
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • In the small intestine, proglucagon is processed into the previously characterized peptide "glicentin" (proglucagon (PG) 1-69) and two smaller peptides showing about 50% homology with glucagon: glucagon-like peptide-1 and -2. It was assumed that the sites of post-translational cleavage in the small intestine of the proglucagon precursor were determined by pairs of basic amino acid residues flanking the two peptides. Earlier studies have shown that synthetic glucagon-like peptide-1 (GLP-1… CONTINUE READING
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