Complete sequence of p53 gene in 20 patients with lung cancer: comparison with chemosensitivity and immunohistochemistry.

@article{Brattstrm1998CompleteSO,
  title={Complete sequence of p53 gene in 20 patients with lung cancer: comparison with chemosensitivity and immunohistochemistry.},
  author={Daniel Brattstr{\"o}m and Michael Bergqvist and Kristina Lamberg and Wolfgang Kraaz and L Scheibenflug and G{\"o}ran Gustafsson and Mats Ingan{\"a}s and Gunnar Wagenius and Ola Brodin},
  journal={Medical oncology},
  year={1998},
  volume={15 4},
  pages={255-61}
}
In this study the entire p53 complementary DNA has been sequenced in 20 non-small cell lung carcinomas (NSCLC) and the results correlated with chemosensitivity, immunohistochemistry and clinical data. Ten patients had mutations in p53, 8 missense mutations and 2 nonsense mutations. The method discovered two mutations never described previously and two other mutations that have never been described before in connection with NSCLC tumours. Chemosensitivity data, according to a short-term assay… CONTINUE READING

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